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KMID : 0928320080080030201
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Korean Journal of Health Promotion and Disease Prevention
2008 Volume.8 No. 3 p.201 ~ p.207
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Change of Serum hsCRP Concentration after Statin Therapy in Dyslipidemic Patients
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Lim Jie-Hyang
Kim Young-Joo
Lee Sang-Yeoup
Kim Yun-Jin
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Abstract
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Background: Statins lowers the hsCRP, a marker of inflammation. There are few study of change in plasma concentration of hsCRP after statin therapy in Korea. The purpose of this study is to determine the change in plasma hsCRP concentration after statin therapy.
Methods: We studied 156 patients who were visited a department of family medicine at a university hospital and diagnosed with dyslipidemia between May 2002 and May 2005. We reviewed chart retrospectively. The statin group is participated of 69 patients who were treated with diet/exercise and statin. The control group is 87 patients who were treated with only diet/exercise. The hsCRP and total cholesterol concentration was measured in serum on each visit that days 0, 40, 180, 360. We analyzed correlation between change of hsCRP concentration and change of total cholesterol. we analyzed difference of change of hsCRP and total cholesterol at each visit in two groups.
Results: In statin group, mean baseline loghsCRP was -1.115±0.509mg/dL. The differences loghsCRP between baseline and second(after 180 days) and third visit(after 360 days) were respectively -1.337±0.318mg/dL and -1.359±0.383mg/dL(P<0.05). Correlation between reduction of hsCRP concentration and reduction of total cholesterol was not significantly. In control group, there were no significant differences in means of loghsCRP at the each visit.
Conclusions: Longtime statin therapy lowered serum hsCRP concentration without correlated reduction of total cholesterol then can play the role of reduction of cardiovascular disease.
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KEYWORD
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statin, dyslipidemia, hsCRP
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